Recommendations for Redesign: Revising the Rochester Museum and Science Center\u27s Native Peoples of the Americas Exhibit

This thesis proposes methods for redesigning the Rochester Museum and Science Center’s (RMSC) Native Peoples of the Americas exhibit to ensure better representation of the Native cultures it displays. Explorations of these methods include a survey of the current exhibit, focusing on specific areas and design elements that need to be addressed, as well as brief comparative surveys of other Native American and ethnographic exhibits at the RMSC as well as exhibits at Ganondagan State Historic Site and the New York and Washington branches of the National Museum of the American Indian. The literature review considers the history of Native American collections and representation in American museums and provides some suggested methods for the redesign of Native American exhibits that have been put forth by museum professionals, historians, and members of Native American communities over the past 25 years. This thesis also includes primary research in the form of an interview with the Senior Director for Collections and Exhibits at the RMSC to learn the themes and concepts anticipated by the museum in the coming years, as well as visitor observations and summary reporting conducted by the author from November 2017 through February 2018 examining how the RMSC’s visitors currently use the exhibit and how to improve their experience within it. The result of this work is a series of recommendations for the RMSC’s collections and exhibitions staff to consider as they work to redesign Native Peoples of the Americas over the next several years

A White Light Megaflare on the dM4.5e Star YZ CMi

On UT 2009 January 16, we observed a white light megaflare on the dM4.5e star YZ CMi as part of a long-term spectroscopic flare-monitoring campaign to constrain the spectral shape of optical flare continuum emission. Simultaneous U-band photometric and 3350A-9260A spectroscopic observations were obtained during 1.3 hours of the flare decay. The event persisted for more than 7 hours and at flare peak, the U-band flux was almost 6 magnitudes brighter than in the quiescent state. The properties of this flare mark it as one of the most energetic and longest-lasting white light flares ever to be observed on an isolated low-mass star. We present the U-band flare energetics and a flare continuum analysis. For the first time, we show convincingly with spectra that the shape of the blue continuum from 3350A to 4800A can be represented as a sum of two components: a Balmer continuum as predicted by the Allred et al radiative hydrodynamic flare models and a T ~ 10,000K blackbody emission component as suggested by many previous studies of the broadband colors and spectral distributions of flares. The areal coverage of the Balmer continuum and blackbody emission regions vary during the flare decay, with the Balmer continuum emitting region always being significantly (~3-16 times) larger. These data will provide critical constraints for understanding the physics underlying the mysterious blue continuum radiation in stellar flares.Comment: 12 pages, 4 figures, accepted by Astrophysical Journal Letter

The periodic variations of a white-light flare observed with ULTRACAM

High time resolution observations of a white-light flare on the active star EQ PegB show evidence of intensity variations with a period of ≈10 s. The period drifts to longer values during the decay phase of the flare. If the oscillation is interpreted as an impulsively-excited, standing-acoustic wave in a flare loop, the period implies a loop length of ≈3.4 Mm and ≈6.8 Mm for the case of the fundamental mode and the second harmonic, respectively. However, the small loop lengths imply a very high modulation depth making the acoustic interpretation unlikely. A more realistic interpretation may be that of a fast-MHD wave, with the modulation of the emission being due to the magnetic field. Alternatively, the variations could be due to a series of reconnection events. The periodic signature may then arise as a result of the lateral separation of individual flare loops or current sheets with oscillatory dynamics (i.e., periodic reconnection)

Oceanic evidence of climate change in southern Australia over the last three centuries

Author Posting. © American Geophysical Union, 2004. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geophysical Research Letters 31 (2004): L07212, doi:10.1029/2003GL018869.Chemical analysis of deepwater octocorals collected at 1000 m depth off southern Australia indicates long-term cooling, beginning in the mid-18th century. This cooling appears to reflect shoaling of isotherms along the continental shelf, that can be related statistically, observationally and by modeling to increasing coastal sea-surface temperatures, that in turn reflect a poleward extension of the SW Pacific boundary current (the East Australian Current). The oceanographic changes implied by the coral record suggest climate change in temperate Australia starting about the time of European settlement. Correlations between temperate Australian and Antarctic indices suggest these long-term changes might also be relevant to Antarctic climate.This study was supported by the Australian Fisheries and Research Development Corporation, the Australian Greenhouse Office, and the Land and Water Research Development Corporation

Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial.

BACKGROUND: Staphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed treatment failure or disease recurrence, or death, by enhancing early S aureus killing, sterilising infected foci and blood faster, and reducing risks of dissemination and metastatic infection. METHODS: In this multicentre, randomised, double-blind, placebo-controlled trial, adults (≥18 years) with S aureus bacteraemia who had received ≤96 h of active antibiotic therapy were recruited from 29 UK hospitals. Patients were randomly assigned (1:1) via a computer-generated sequential randomisation list to receive 2 weeks of adjunctive rifampicin (600 mg or 900 mg per day according to weight, oral or intravenous) versus identical placebo, together with standard antibiotic therapy. Randomisation was stratified by centre. Patients, investigators, and those caring for the patients were masked to group allocation. The primary outcome was time to bacteriologically confirmed treatment failure or disease recurrence, or death (all-cause), from randomisation to 12 weeks, adjudicated by an independent review committee masked to the treatment. Analysis was intention to treat. This trial was registered, number ISRCTN37666216, and is closed to new participants. FINDINGS: Between Dec 10, 2012, and Oct 25, 2016, 758 eligible participants were randomly assigned: 370 to rifampicin and 388 to placebo. 485 (64%) participants had community-acquired S aureus infections, and 132 (17%) had nosocomial S aureus infections. 47 (6%) had meticillin-resistant infections. 301 (40%) participants had an initial deep infection focus. Standard antibiotics were given for 29 (IQR 18-45) days; 619 (82%) participants received flucloxacillin. By week 12, 62 (17%) of participants who received rifampicin versus 71 (18%) who received placebo experienced treatment failure or disease recurrence, or died (absolute risk difference -1·4%, 95% CI -7·0 to 4·3; hazard ratio 0·96, 0·68-1·35, p=0·81). From randomisation to 12 weeks, no evidence of differences in serious (p=0·17) or grade 3-4 (p=0·36) adverse events were observed; however, 63 (17%) participants in the rifampicin group versus 39 (10%) in the placebo group had antibiotic or trial drug-modifying adverse events (p=0·004), and 24 (6%) versus six (2%) had drug interactions (p=0·0005). INTERPRETATION: Adjunctive rifampicin provided no overall benefit over standard antibiotic therapy in adults with S aureus bacteraemia. FUNDING: UK National Institute for Health Research Health Technology Assessment

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication

Is a first year multi-activity orientation program effective at developing relationships between students, their peers, staff and faculty?

ABSTRACT First year orientation activities at post-secondary institutions serve the purpose of facilitating peer-to-peer and peer-to-instructor relationships [1,2]. It has been shown that the creation of these relationships is positively correlated with increased student retention rates [2-4]. Several studies have evaluated activities pertaining to outdoor/physical education, small focus groups, program and faculty information sessions, and facility orientation to try and determine which are most effective in increasing student outcomes [1-4]. However, little research has been conducted to date regarding the evaluation and effectiveness of multi-activity programs. Therefore, the primary purpose of this study is to assess the effectiveness of first year orientation activities (e.g., peer mentoring, outdoor team building) in an Ontario university Kinesiology program for developing relationships between first year students and others within the department. It is hoped that by improving these relationships, there will be an associated long term increase in academic achievement and retention rates. Each winter semester over the next five years, first year undergraduate students will complete an online survey regarding their orientation experiences from the previous fall. The survey will ask students to reflect on their first year orientation experiences and provide feedback on how effective they thought each activity was at orienting them to the campus, developing relationships among their peers, staff and faculty, and other success criteria. Quantitative results will be summarized using descriptive statistics and stratified based on factors such as year and sex. Qualitative responses will be assessed using open and axial coding techniques using QSR Nvivo software. The results of these analyses will be used to modify orientation activities in future years, with the intent of improving relationships between students, staff, and faculty on a continual basis. The first set of analyzed data regarding Fall 2015 orientation will be available at the time of UWill Discover in March. REFERENCES [1] Bell, B. J. (2006). Wilderness orientation: Exploring the relationship between college preorientation programs and social support. Journal of Experiential Education, 29(2), 145-167. [2] Power, R. K., Miles, B., Peruzzi, A., & Voerman, A. (2011). Building bridges: A practical guide to developing and implementing a subject-specific peer-to-peer academic mentoring program for first-year higher education students. Asian Social Science, 7(11), 75-80. [3] Price, D. V., & Lee, M. (2005). Learning communities and student success in postsecondary education [PDF]. New York City: MDRC. [4] Wolfe, B. D., & Kay, G. (2001). Perceived impact of an outdoor orientation program for first-year university students. Journal of Experiential Education, 34(1), 19-34